产品
编 号：F741512
分子式：C22H28FN3O4S
分子量：449.54
分子式：C22H28FN3O4S
分子量：449.54
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
1mg
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5mg
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10mg
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25mg
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结构图
CAS No: 2360853-16-1
产品详情
生物活性：
RBN-3143 is a potent and NAD+-competitive catalytic PARP14 inhibitor with an IC50 value of 4 nM. RBN-3143 inhibits PARP14-mediated ADP-ribosylation and stabilizes PARP14 in cell lines. RBN-3143 can be used in research of lung inflammation.
体内研究：
RBN-3143 (5 μg; 鼻内给药) 可改善类固醇耐药哮喘小鼠模型。Animal Model:Mouse of asthma models
Dosage:5 ug
Administration:Intranasal administration
Result:Suppressed the accumulation of alarmins TSLP, IL-33, and IL-25.
RBN-3143 is a potent and NAD+-competitive catalytic PARP14 inhibitor with an IC50 value of 4 nM. RBN-3143 inhibits PARP14-mediated ADP-ribosylation and stabilizes PARP14 in cell lines. RBN-3143 can be used in research of lung inflammation.
体内研究：
RBN-3143 (5 μg; 鼻内给药) 可改善类固醇耐药哮喘小鼠模型。Animal Model:Mouse of asthma models
Dosage:5 ug
Administration:Intranasal administration
Result:Suppressed the accumulation of alarmins TSLP, IL-33, and IL-25.
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