产品
编 号：F741569
分子式：C22H21N3O3
分子量：375.42
分子式：C22H21N3O3
分子量：375.42
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CAS No: 2415761-65-6
产品详情
生物活性：
Tubulin inhibitor 24 is a potent tubulin inhibitor. Tubulin inhibitor 24 inhibits tubulin polymerization. Tubulin inhibitor 24 induces cell cycle arrest at the G2/M phase in a concentration-dependent manner. Tubulin inhibitor 24 shows antitumor activity with no obvious toxicity.
体内研究：
Tubulin inhibitor 24 (10, 20 mg/kg; i.p.; per day for 16 days) shows antitumor activity with no obvious toxicity.Animal Model:4-6 weeks, male C57/BL mice (B16e-10 tumor model)
Dosage:10, 20 mg/kg (formulated in 5% DMSO, 40% PEG-300 and 55% saline)
Administration: I.p.; per day, 16 days
Result:Showed antitumor activity with no obvious toxicity.
体外研究：
Tubulin inhibitor 24 (compound 1b) () shows high antiproliferative activity with IC50s of 0.021, 0.047, 0.003, 0.048 μM for Hela, MCF-7, A549, HCT-116, B16-F10 cells, respectively.Tubulin inhibitor 24 inhibites tubulin polymerization with an IC50 value of 2.1 μM.Tubulin inhibitor 24 (5, 10 nM) induces cell cycle arrest at the G2/M phase in a concentration-dependent manner.Tubulin inhibitor 24 (10, 20, 40 nM; 24 h) inhibits MCF-7 cancer cells migration in a dose-dependent manner.Tubulin inhibitor 24 (40 nM; 6 h) destabilizes microtubule by inhibiting tubulin polymerization and disturbing microtubule networks in B16-F10 cells.
Tubulin inhibitor 24 is a potent tubulin inhibitor. Tubulin inhibitor 24 inhibits tubulin polymerization. Tubulin inhibitor 24 induces cell cycle arrest at the G2/M phase in a concentration-dependent manner. Tubulin inhibitor 24 shows antitumor activity with no obvious toxicity.
体内研究：
Tubulin inhibitor 24 (10, 20 mg/kg; i.p.; per day for 16 days) shows antitumor activity with no obvious toxicity.Animal Model:4-6 weeks, male C57/BL mice (B16e-10 tumor model)
Dosage:10, 20 mg/kg (formulated in 5% DMSO, 40% PEG-300 and 55% saline)
Administration: I.p.; per day, 16 days
Result:Showed antitumor activity with no obvious toxicity.
体外研究：
Tubulin inhibitor 24 (compound 1b) () shows high antiproliferative activity with IC50s of 0.021, 0.047, 0.003, 0.048 μM for Hela, MCF-7, A549, HCT-116, B16-F10 cells, respectively.Tubulin inhibitor 24 inhibites tubulin polymerization with an IC50 value of 2.1 μM.Tubulin inhibitor 24 (5, 10 nM) induces cell cycle arrest at the G2/M phase in a concentration-dependent manner.Tubulin inhibitor 24 (10, 20, 40 nM; 24 h) inhibits MCF-7 cancer cells migration in a dose-dependent manner.Tubulin inhibitor 24 (40 nM; 6 h) destabilizes microtubule by inhibiting tubulin polymerization and disturbing microtubule networks in B16-F10 cells.
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