产品
编 号：F741636
分子式：C26H27N5O2
分子量：441.52
分子式：C26H27N5O2
分子量：441.52
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 2494198-61-5
产品详情
生物活性：
Miclxin (DS37262926) is a potent inhibitor of mutant β-catenin, involving in Wnt signaling pathway. Miclxin induces β-catenin-dependent apoptosis, leads to severe mitochondrial damage with the loss of mitochondrial membrane. Miclxin kills tumor via targeting to MIC60, a major components of the mitochondrial contact site and cristae organizing system (MICOS) complex.
体外研究：
Miclxin (0-15 μM; 48 h) 抑制 β-catenin 突变的 HCT116 细胞和等基因 HCT116 细胞 (CTNNB1 Δ45/-) 的生长，(10 μM; 24 h) 诱导 HCT116 细胞凋亡。
Miclxin (DS37262926) is a potent inhibitor of mutant β-catenin, involving in Wnt signaling pathway. Miclxin induces β-catenin-dependent apoptosis, leads to severe mitochondrial damage with the loss of mitochondrial membrane. Miclxin kills tumor via targeting to MIC60, a major components of the mitochondrial contact site and cristae organizing system (MICOS) complex.
体外研究：
Miclxin (0-15 μM; 48 h) 抑制 β-catenin 突变的 HCT116 细胞和等基因 HCT116 细胞 (CTNNB1 Δ45/-) 的生长，(10 μM; 24 h) 诱导 HCT116 细胞凋亡。
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