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编 号：F070562
分子式：C27H25N5O2
分子量：451.52
分子式：C27H25N5O2
分子量：451.52
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CAS No: 1206711-14-9
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生物活性：
DMH2 is a potent BMP receptor antagonist. DMH2 downregulates the expression of Id1 and Id3 proteins, and inhibits the proliferation and induces cell death of lung cancer cell lines.
体内研究：
DMH2 (0-2 mg/kg, IP, twice daily, for 2 days prior to PH (partial hepatectomy) and for 2 days after PH) increases hepatocyte proliferation from 13.7% to 26.9% at 2 mg/kg.Animal Model:C57BL/6 mice (7-8 weeks, male)
Dosage:0.5, 1, 2 mg/kg
Administration:IP, twice daily, for 2 days prior to PH and for 2 days after PH (partial hepatectomy)
Result:Increased hepatocyte proliferation from 13.7% to 26.9% at 2 mg/kg.
体外研究：
DMH2 decreases expression of Id1 and Id3 and causes growth suppression of three lung cancer cell lines with K-Ras mutation (A549, H157, H727) and three without a K-Ras mutation (H1299, H865, U1752).The combination of DMH2 and PP2 causes significantly greater reduction in Id1 promoter activity and growth inhibition than either agent alone in the A549 cells.
DMH2 is a potent BMP receptor antagonist. DMH2 downregulates the expression of Id1 and Id3 proteins, and inhibits the proliferation and induces cell death of lung cancer cell lines.
体内研究：
DMH2 (0-2 mg/kg, IP, twice daily, for 2 days prior to PH (partial hepatectomy) and for 2 days after PH) increases hepatocyte proliferation from 13.7% to 26.9% at 2 mg/kg.Animal Model:C57BL/6 mice (7-8 weeks, male)
Dosage:0.5, 1, 2 mg/kg
Administration:IP, twice daily, for 2 days prior to PH and for 2 days after PH (partial hepatectomy)
Result:Increased hepatocyte proliferation from 13.7% to 26.9% at 2 mg/kg.
体外研究：
DMH2 decreases expression of Id1 and Id3 and causes growth suppression of three lung cancer cell lines with K-Ras mutation (A549, H157, H727) and three without a K-Ras mutation (H1299, H865, U1752).The combination of DMH2 and PP2 causes significantly greater reduction in Id1 promoter activity and growth inhibition than either agent alone in the A549 cells.
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