产品
编 号：F741721
分子式：C19H16N4O2S
分子量：364.42
分子式：C19H16N4O2S
分子量：364.42
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规格
价格
是否有货
1mg
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5mg
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10mg
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25mg
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50mg
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100mg
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结构图
CAS No: 2687970-96-1
产品详情
生物活性：
TDI-011536 is a potent Lats kinase inhibitor, interrupts Hippo-Yap signaling and initiates the proliferation of lesioned heartmuscle cells. TDI-011536 can be used in studies of organ conservation and regeneration.
体内研究：
TDI-011536 (200 mg/kg；腹腔注射；一次) 在肝脏、心脏和皮肤中提供超过 4 小时的持续抑制，并在注射后至少 4 小时内减少所有三个器官中的 pYap 量。 TDI-011536 (100 mg/kg；腹腔注射；每天一次，持续 2 或 3 天) 显示出对心肌细胞的增殖作用。Animal Model:Living mice (immunoblot analysis of the heart, liver, and skin immediately after injection).
Dosage:200 mg/kg
Administration:Intraperitoneal injections; once.
Result:Reduced the amount of pYap for at least 4 h after injection in all three organs and the levels returned to control values within a day.
Animal Model:Male 8-week-old mice (cryolesion model).
Dosage:100 mg/kg
Administration:Intraperitoneal injections; once daily for 2 or 3 days.
Result:Promoted cardiomyocytes proliferation.
体外研究：
TDI-011536 (3 μM；24 小时) 降低 Yap 磷酸化并 (3 μM；5 天) 诱导人视网膜类器官中 Müller 胶质细胞的增殖。
TDI-011536 is a potent Lats kinase inhibitor, interrupts Hippo-Yap signaling and initiates the proliferation of lesioned heartmuscle cells. TDI-011536 can be used in studies of organ conservation and regeneration.
体内研究：
TDI-011536 (200 mg/kg；腹腔注射；一次) 在肝脏、心脏和皮肤中提供超过 4 小时的持续抑制，并在注射后至少 4 小时内减少所有三个器官中的 pYap 量。 TDI-011536 (100 mg/kg；腹腔注射；每天一次，持续 2 或 3 天) 显示出对心肌细胞的增殖作用。Animal Model:Living mice (immunoblot analysis of the heart, liver, and skin immediately after injection).
Dosage:200 mg/kg
Administration:Intraperitoneal injections; once.
Result:Reduced the amount of pYap for at least 4 h after injection in all three organs and the levels returned to control values within a day.
Animal Model:Male 8-week-old mice (cryolesion model).
Dosage:100 mg/kg
Administration:Intraperitoneal injections; once daily for 2 or 3 days.
Result:Promoted cardiomyocytes proliferation.
体外研究：
TDI-011536 (3 μM；24 小时) 降低 Yap 磷酸化并 (3 μM；5 天) 诱导人视网膜类器官中 Müller 胶质细胞的增殖。
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