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编 号:F741755
分子式:C22H17N5O
分子量:367.4
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生物活性:
LolCDE-IN-2 is a potent Lol protein (LolCDE) inhibitor. LolCDE-IN-2 inhibits E. coli MG1655 with a MIC of 2 μg/ml. Antibacterial activity.

体外研究:
The P. aeruginosa ΔlolCDE::CTX-lolCDEE. colistrain becomes more susceptible to LolCDE-IN-2 (compound 2A) when either the MexAB-OprM efflux pump is lacking or the permeability of its OM is increased by the expression of the FpvA-ΔP protein; in each case, these strains show an MIC of 16?μg/ml.
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