产品
编 号：F741786
分子式：C20H11Cl2F3N2O4S
分子量：503.28
分子式：C20H11Cl2F3N2O4S
分子量：503.28
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
结构图
CAS No: 2763260-36-0
产品详情
生物活性：
NRX-103094 is a potent enhancer of the interaction between β-catenin, and its cognate E3 ligase, SCFβ-TrCP. NRX-103094 enhances the binding of pSer33/Ser37 β-catenin peptide for β-TrCP with an EC50 of 62 nM and a Kd of 0.6 nM.
体外研究：
NRX-103094 shows high potency with pSer33/Ser37 β-catenin peptide (EC50?of?457?nM). NRX-103094 potentiates the ubiquitylation of pSer33/S37A β-catenin peptide to levels greater than wild-type pSer33/pSer37 levels at 250?nM.NRX-103094 enhances the S33E/S37A phosphomimetic peptide binding affinity for β-TrCP from >5?μM in the absence of compound to 22?nM in the presence of 40?μM compound. In the presence of 20?μM NRX-103094, robust time-dependent ubiquitylation of S33E/S37A β-catenin peptide is observed. Likewise, the full-length S33E/S37A β-catenin protein is strongly ubiquitylated in the presence of 20?μM NRX-103094, with the ubiquitylation levels approaching that of WT full-length β-catenin protein.
NRX-103094 is a potent enhancer of the interaction between β-catenin, and its cognate E3 ligase, SCFβ-TrCP. NRX-103094 enhances the binding of pSer33/Ser37 β-catenin peptide for β-TrCP with an EC50 of 62 nM and a Kd of 0.6 nM.
体外研究：
NRX-103094 shows high potency with pSer33/Ser37 β-catenin peptide (EC50?of?457?nM). NRX-103094 potentiates the ubiquitylation of pSer33/S37A β-catenin peptide to levels greater than wild-type pSer33/pSer37 levels at 250?nM.NRX-103094 enhances the S33E/S37A phosphomimetic peptide binding affinity for β-TrCP from >5?μM in the absence of compound to 22?nM in the presence of 40?μM compound. In the presence of 20?μM NRX-103094, robust time-dependent ubiquitylation of S33E/S37A β-catenin peptide is observed. Likewise, the full-length S33E/S37A β-catenin protein is strongly ubiquitylated in the presence of 20?μM NRX-103094, with the ubiquitylation levels approaching that of WT full-length β-catenin protein.
产品资料
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