产品
编 号：F741818
分子式：C16H16ClN5
分子量：313.78
分子式：C16H16ClN5
分子量：313.78
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
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1mg
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5mg
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10mg
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25mg
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结构图
CAS No: 2810887-45-5
产品详情
生物活性：
TDI-10229 is a potent and orally bioavailable inhibitor of soluble adenylyl cyclase (sAC, ADCY10). TDI-10229 displays nanomolar inhibition of sAC in both biochemical and cellular assays (IC50 of 195 nM) and exhibits mouse pharmacokinetic properties sufficient to warrant its use as an in vivo tool compound.
体内研究：
TDI-10229 (5 mg/kg；po) 处理显示 Cmax、AUC 和 MRT 分别为 15.5 μM、94 μg h/mL 和 3.95 小时。Animal Model:Mouse
Dosage:20 mg/kg
Administration:P.o.(Pharmacokinetic Analysis)
Result:The Cmax, AUC and MRT were 15.5 μM, 94 μg h/mL and 3.95 hours, respectively.
体外研究：
TDI-10229 具有良好的渗透性，对人 4-4 细胞的 IC50 为 92 nM。
TDI-10229 is a potent and orally bioavailable inhibitor of soluble adenylyl cyclase (sAC, ADCY10). TDI-10229 displays nanomolar inhibition of sAC in both biochemical and cellular assays (IC50 of 195 nM) and exhibits mouse pharmacokinetic properties sufficient to warrant its use as an in vivo tool compound.
体内研究：
TDI-10229 (5 mg/kg；po) 处理显示 Cmax、AUC 和 MRT 分别为 15.5 μM、94 μg h/mL 和 3.95 小时。Animal Model:Mouse
Dosage:20 mg/kg
Administration:P.o.(Pharmacokinetic Analysis)
Result:The Cmax, AUC and MRT were 15.5 μM, 94 μg h/mL and 3.95 hours, respectively.
体外研究：
TDI-10229 具有良好的渗透性，对人 4-4 细胞的 IC50 为 92 nM。
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