产品
编 号：F742004
分子式：C22H29NO9
分子量：451.47
分子式：C22H29NO9
分子量：451.47
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CAS No: 101626-66-8
产品详情
生物活性：
Dobutamine tartrate is a synthetic catecholamine that acts on α1-AR, β1-AR, β2-AR (α-1, β-1 andβ-2 adrenoceptors). Dobutamine tartrate is a selective β1-AR agonist, relatively weak activity at α1-AR and β2-AR. Dobutamine tartrate can increase cardiac output and correct hypoperfusion.
体内研究：
Dobutamine tartrate has a rapid onset of action and a short half-life .Dobutamine tartrate (0.15-20 mg/kg; i.p.) results in subsequent increase in the left ventricular function and heart rate acceleration with an increasing dose in wildtype mice.Dobutamine tartrate results in significant inotropic, lusitropic, and chronotropic cardiac response with a high dose in wildtype mice.Low doses of Dobutamine tartrate significantly increases inotropic and lusitropic cardiac performance without chronotropic changes in the Tgαq*44 mice.Dobutamine tartrate increases heart rate only after high doses, but then inotropic and lusitropic cardiac functional reserve is lost.Dobutamine tartrate increases alveolar liquid clearance in ventilated rats by beta-2 receptor stimulation.Animal Model:Tgαq*44 mice (heart failure models)
Dosage:0.15 mg/kg, 0.5 mg/kg as a low dose, 1.5 mg/kg, 5 mg/kg, 20 mg/kg as a high dose
Administration:Intraperitoneal injection
Result:Induced different response in cardiac function on a low and high dose in mice with with heart failure.
Dobutamine tartrate is a synthetic catecholamine that acts on α1-AR, β1-AR, β2-AR (α-1, β-1 andβ-2 adrenoceptors). Dobutamine tartrate is a selective β1-AR agonist, relatively weak activity at α1-AR and β2-AR. Dobutamine tartrate can increase cardiac output and correct hypoperfusion.
体内研究：
Dobutamine tartrate has a rapid onset of action and a short half-life .Dobutamine tartrate (0.15-20 mg/kg; i.p.) results in subsequent increase in the left ventricular function and heart rate acceleration with an increasing dose in wildtype mice.Dobutamine tartrate results in significant inotropic, lusitropic, and chronotropic cardiac response with a high dose in wildtype mice.Low doses of Dobutamine tartrate significantly increases inotropic and lusitropic cardiac performance without chronotropic changes in the Tgαq*44 mice.Dobutamine tartrate increases heart rate only after high doses, but then inotropic and lusitropic cardiac functional reserve is lost.Dobutamine tartrate increases alveolar liquid clearance in ventilated rats by beta-2 receptor stimulation.Animal Model:Tgαq*44 mice (heart failure models)
Dosage:0.15 mg/kg, 0.5 mg/kg as a low dose, 1.5 mg/kg, 5 mg/kg, 20 mg/kg as a high dose
Administration:Intraperitoneal injection
Result:Induced different response in cardiac function on a low and high dose in mice with with heart failure.
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