产品
编 号：F742067
分子式：C8H5N3OS
分子量：191.21
分子式：C8H5N3OS
分子量：191.21
产品类型
规格
价格
是否有货
结构图
CAS No: 1023814-45-0
产品详情
生物活性：
OUL245 is a 7-Hydroxy derivative, and a selectively PARP2 inhibitor (IC50=44 nM). OUL245 also inhibits other PARP and TNKS enzymes with IC50s of 2.9-8.8 μM.
体外研究：
OUL245 (1 μM; 10-12 d) 与其他衍生物不同，它不能拯救过表达 PARP10 的细胞，使其免于 ADP 核糖化依赖的细胞死亡。药代动力学分析water solubility μg/mLGI Papp×10-6 cm/s (RM %)BBB Papp×10-6 cm/s (RM %)metabolic stablity %stab in human plasmastab. in MeOHstab in PBS pH 7.4
24.910.0190.16495.05>24>24>24
OUL245 is a 7-Hydroxy derivative, and a selectively PARP2 inhibitor (IC50=44 nM). OUL245 also inhibits other PARP and TNKS enzymes with IC50s of 2.9-8.8 μM.
体外研究：
OUL245 (1 μM; 10-12 d) 与其他衍生物不同，它不能拯救过表达 PARP10 的细胞，使其免于 ADP 核糖化依赖的细胞死亡。药代动力学分析water solubility μg/mLGI Papp×10-6 cm/s (RM %)BBB Papp×10-6 cm/s (RM %)metabolic stablity %stab in human plasmastab. in MeOHstab in PBS pH 7.4
24.910.0190.16495.05>24>24>24
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