产品
编 号：F742551
分子式：C20H20F3NO4
分子量：395.37
分子式：C20H20F3NO4
分子量：395.37
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CAS No: 1111078-63-7
产品详情
生物活性：
SCD1-IN-1 is a SCD1 inhibitor (IC50: 5.8 nM). SCD1-IN-1 can be used in the research of dermatologic condition.
体内研究：
SCD1-IN-1 (compound I, 1.5% w/v, 25 μL, applied to surfaces of ears) reduces in cholesterol ester (CE) and wax ester (WE) production in hamster ear model.Animal Model:Hamster ear model
Dosage:1.5% in a vehicle of propylene glycol/transcutanol/ethanol 20/20/60, w/v, 25 μL.
Administration:Applied to ~3 cm2 of the ventral surfaces of both the right and left ears, twice daily for 2 weeks.
Result:Resulted in a 62% reduction in CE and an 82% reduction in WE, a mechanism biomarker for sebum production in the hamster model, and a reduction in sebaceous gland size.
体外研究：
SCD1-IN-1 (compound I, 6 days) inhibits the SCD1 enzyme in intact human cells, with an IC50 value of 6.8 nM.
SCD1-IN-1 is a SCD1 inhibitor (IC50: 5.8 nM). SCD1-IN-1 can be used in the research of dermatologic condition.
体内研究：
SCD1-IN-1 (compound I, 1.5% w/v, 25 μL, applied to surfaces of ears) reduces in cholesterol ester (CE) and wax ester (WE) production in hamster ear model.Animal Model:Hamster ear model
Dosage:1.5% in a vehicle of propylene glycol/transcutanol/ethanol 20/20/60, w/v, 25 μL.
Administration:Applied to ~3 cm2 of the ventral surfaces of both the right and left ears, twice daily for 2 weeks.
Result:Resulted in a 62% reduction in CE and an 82% reduction in WE, a mechanism biomarker for sebum production in the hamster model, and a reduction in sebaceous gland size.
体外研究：
SCD1-IN-1 (compound I, 6 days) inhibits the SCD1 enzyme in intact human cells, with an IC50 value of 6.8 nM.
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