产品
编 号：F072003
分子式：C24H23N3O5
分子量：433.46
分子式：C24H23N3O5
分子量：433.46
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
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5mg
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10mg
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25mg
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50mg
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100mg
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结构图
CAS No: 1210004-12-8
产品详情
生物活性：
JZL195 is a selective and efficacious dual fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) inhibitor with IC50s of 2 and 4 nM, respectively.
体内研究：
JZL195 (20 mg/kg; i.p.) produces an antinociceptive response in the tail immersion assay.Animal Model:Male C57BL/6J mice
Dosage:20 mg/kg
Administration:Intraperitoneal injection
Result:Produced a much greater antinociceptive response in the tail immersion assay compared with inhibitors of either FAAH or MAGL alone.
体外研究：
JZL195 produces near-complete blockade of FP-Rh labeling of both mouse brain FAAH and MAGL at concentrations as low as 100 nM (IC50 values of 13 and 19 nM, respectively).JZL195 inhibits rat and human FAAH and MAGL enzymes with IC50 values in the range of ≈10-100 nM based on competitive ABPP assays.
JZL195 is a selective and efficacious dual fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) inhibitor with IC50s of 2 and 4 nM, respectively.
体内研究：
JZL195 (20 mg/kg; i.p.) produces an antinociceptive response in the tail immersion assay.Animal Model:Male C57BL/6J mice
Dosage:20 mg/kg
Administration:Intraperitoneal injection
Result:Produced a much greater antinociceptive response in the tail immersion assay compared with inhibitors of either FAAH or MAGL alone.
体外研究：
JZL195 produces near-complete blockade of FP-Rh labeling of both mouse brain FAAH and MAGL at concentrations as low as 100 nM (IC50 values of 13 and 19 nM, respectively).JZL195 inhibits rat and human FAAH and MAGL enzymes with IC50 values in the range of ≈10-100 nM based on competitive ABPP assays.
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