产品
编 号：F073953
分子式：C32H40N2O5S
分子量：564.74
分子式：C32H40N2O5S
分子量：564.74
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
1mg
询价
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5mg
询价
询价
10mg
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询价
50mg
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结构图
CAS No: 121345-64-0
产品详情
生物活性：
SR33805 is a potent Ca2+ channel antagonist, with EC50s of 4.1 nM and 33 nM in depolarized and polarized conditions, respectively. SR33805 blocks L-type but not T-type Ca2+ channels. SR33805 can be used for the research of acute or chronic failing hearts.
体内研究：
SR33805 (20 mg/kg; a single i.p.) improves end-systolic strain and fractional shortening of MI hearts in rats.SR33805 (5 mg/kg/day; p.o. for 38 d) significantly reduces intimal hyperplasia in pigs.Animal Model:Male Wistar rats (5 weeks) are subjected to coronary artery ligature
Dosage:0.2, 2, 20 mg/kg
Administration:A single i.p. injection
Result:Increased significantly both end-systolic strain (ESS) and fractional shortening (FS) by about +38 and +26%, respectively at the dose of 20 mg/kg.Did not affect other contractile parameters.
体外研究：
SR33805 (0.01-10 μM; 3 d) inhibits growth factor-induced proliferation of SMC (0.20SR33805 相关抗体:Cell Viability AssayCell Line:Smooth muscle cells (SMC)
Concentration:0.01, 0.1, 1, 10 μM
Incubation Time:3 days
Result:Inhibited in a dose-dependent manner FCS-, bFGF and PDGF-induced proliferation of porcine SMC with IC50s of 0.26±0.08, 0.46±0.1 and 0.20±0.04 μM, respectively.
SR33805 is a potent Ca2+ channel antagonist, with EC50s of 4.1 nM and 33 nM in depolarized and polarized conditions, respectively. SR33805 blocks L-type but not T-type Ca2+ channels. SR33805 can be used for the research of acute or chronic failing hearts.
体内研究：
SR33805 (20 mg/kg; a single i.p.) improves end-systolic strain and fractional shortening of MI hearts in rats.SR33805 (5 mg/kg/day; p.o. for 38 d) significantly reduces intimal hyperplasia in pigs.Animal Model:Male Wistar rats (5 weeks) are subjected to coronary artery ligature
Dosage:0.2, 2, 20 mg/kg
Administration:A single i.p. injection
Result:Increased significantly both end-systolic strain (ESS) and fractional shortening (FS) by about +38 and +26%, respectively at the dose of 20 mg/kg.Did not affect other contractile parameters.
体外研究：
SR33805 (0.01-10 μM; 3 d) inhibits growth factor-induced proliferation of SMC (0.20SR33805 相关抗体:Cell Viability AssayCell Line:Smooth muscle cells (SMC)
Concentration:0.01, 0.1, 1, 10 μM
Incubation Time:3 days
Result:Inhibited in a dose-dependent manner FCS-, bFGF and PDGF-induced proliferation of porcine SMC with IC50s of 0.26±0.08, 0.46±0.1 and 0.20±0.04 μM, respectively.
产品资料
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