产品
编 号:F744940
分子式:C40H70N8O9
分子量:807.03
产品类型
结构图
CAS No: 141863-45-8
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产品详情
生物活性:
JMV 449 acetate is a potent neurotensin receptor agonist. JMV 449 acetate shows an IC50 of 0.15 nM for inhibition of 125I-neurotensin binding to neonatal mouse brain and an EC50 of 1.9 nM in contracting the guinea-pig ileum. JMV 449 acetate has highly potent and long-lasting hypothermic and analgesic effects in the mouse.
体内研究:
JMV 449 (120 pmol/mouse; i.c.v) shows analgesic effect.Animal Model:Male Swiss albino mice
Dosage:120 pmol/mouse
Administration:I.c.v.
Result:Showed dose-response relation-ships for the analgesic effect.