产品
编 号：F745120
分子式：C19H19N5O4S
分子量：413.45
分子式：C19H19N5O4S
分子量：413.45
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CAS No: 1430095-86-5
产品详情
生物活性：
JAK3-IN-12 (compound 5k) is a highly potent JAK3 inhibitor with IC50 values of 9.5 nM, 18 nM and 42 nM for JAK3, JAK1 and JAK2, respectively. JAK3-IN-12 can be used for researching rheumatoid arthritis.
体内研究：
JAK3-IN-12 (compound 5k) shows moderate AUC, due to its high clearance, which resulted into overall low bioavailability.Pharmacokinetic Parameters of JAK3-IN-12 in male C57BL/6J mice.Tmax (h)Cmax (ng/ml)tmax (h)CL (mL/min/kg), ivAUC0-α (μg/mL·h)F (%)
IV (1 mg/kg);PO (3 mg/kg)0.5146±481.85±0.4340.37 ± 3.61192 ± 5615
Animal Model:Male C57BL/6J mice
Dosage:1 mg/kg for IV; 3 mg/kg for PO
Administration:IV or PO; single dosage
Result:Showed moderate AUC, due to its high clearance, which resulted into overall low bioavailability (15%).
JAK3-IN-12 (compound 5k) is a highly potent JAK3 inhibitor with IC50 values of 9.5 nM, 18 nM and 42 nM for JAK3, JAK1 and JAK2, respectively. JAK3-IN-12 can be used for researching rheumatoid arthritis.
体内研究：
JAK3-IN-12 (compound 5k) shows moderate AUC, due to its high clearance, which resulted into overall low bioavailability.Pharmacokinetic Parameters of JAK3-IN-12 in male C57BL/6J mice.Tmax (h)Cmax (ng/ml)tmax (h)CL (mL/min/kg), ivAUC0-α (μg/mL·h)F (%)
IV (1 mg/kg);PO (3 mg/kg)0.5146±481.85±0.4340.37 ± 3.61192 ± 5615
Animal Model:Male C57BL/6J mice
Dosage:1 mg/kg for IV; 3 mg/kg for PO
Administration:IV or PO; single dosage
Result:Showed moderate AUC, due to its high clearance, which resulted into overall low bioavailability (15%).
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