产品
编 号：F745666
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
结构图
CAS No: 1523164-68-2
产品详情
生物活性：
Prezalumab (AMG 557) is a humanized IgG2 monoclonal antibody targets ICOSL and BAFF. Prezalumab demonstrates beneficial activities on the arthritis of systemic lupus erythematosus. Prezalumab can be used for the research of sjogren's syndrome cutaneous lupus erythematosus, psoriasis and systemic lupus erythematosus (SLE).
体内研究：
Prezalumab shows more efficacious effects than single ICOSL or BAFF inhibitor in mouse NZB/NZW lupus model and collagen induced arthritis (CIA) models.Prezalumab reduces B cell in cynomolgus monkeys, same as the pharmacological effect of BAFF inhibition.1.19Pharmacokinetic Properties of Prezalumab in Cynomolgus Monkeys. Cynomolgus MonkeysIV10 mg/kgCynomolgus MonkeysSC 10 mg/kg
Cmax (μg/mL)264112
Tmax (hr)72
AUC0-inf (μg?hr/mL)2610023800
MRT0-inf (hr)138144
CL (mL/hr/kg)0.3880.427
Vss (mL/kg)52.1
Prezalumab (AMG 557) is a humanized IgG2 monoclonal antibody targets ICOSL and BAFF. Prezalumab demonstrates beneficial activities on the arthritis of systemic lupus erythematosus. Prezalumab can be used for the research of sjogren's syndrome cutaneous lupus erythematosus, psoriasis and systemic lupus erythematosus (SLE).
体内研究：
Prezalumab shows more efficacious effects than single ICOSL or BAFF inhibitor in mouse NZB/NZW lupus model and collagen induced arthritis (CIA) models.Prezalumab reduces B cell in cynomolgus monkeys, same as the pharmacological effect of BAFF inhibition.1.19Pharmacokinetic Properties of Prezalumab in Cynomolgus Monkeys. Cynomolgus MonkeysIV10 mg/kgCynomolgus MonkeysSC 10 mg/kg
Cmax (μg/mL)264112
Tmax (hr)72
AUC0-inf (μg?hr/mL)2610023800
MRT0-inf (hr)138144
CL (mL/hr/kg)0.3880.427
Vss (mL/kg)52.1
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