产品
编 号:F749681
分子式:C26H33N3O4
分子量:451.56
产品类型
结构图
CAS No: 2180973-35-5
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产品详情
生物活性:
Nampt-IN-9 (Compound 8) is a potent NAMPT inhibitor with anticancer activities. Nampt-IN-9 can be used for pancreatic ductal adenocarcinoma research.
体外研究:
Nampt-IN-9 (Compound 8) shows anti-proliferative activity with IC50 values of 0.8, 0.5, 0.004 and 0.6 nM against Jurkat, MIA PaCa-2, BxPC-3, PANC-1 cells, respectively.Nampt-IN-9 (0-1 μM) blunts NAD+ and ATP levels and activates caspase 3 in Jurkat leukemia cells.