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编 号:F750859
分子式:C13H27NO3
分子量:245.36
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生物活性:
Glucocerebrosidase-IN-1 (compound 11a) is a potent and selective GCase (glucocerebrosidase) inhibitor, with an IC50 of 29.3 μM and a Ki of 18.5 μM. Glucocerebrosidase-IN-1 can be used for the research of Gaucher disease (GD) and Parkinson’s disease (PD).

体外研究:
Glucocerebrosidase-IN-1 (compound 11a) is able to enhance GCase activity 1.8-fold in fibroblasts bearing the homozygous L444P mutation.
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