产品
编 号：F751065
产品类型
规格
价格
是否有货
结构图
CAS No: 2305629-50-7
产品详情
生物活性：
Ubamatamab (REGN4018) is a humanized bispecific antibody targeted against Mucin 16 (MUC16) and CD3. Ubamatamab demonstrates potent antitumor activity.
体内研究：
Ubamatamab（REGN4018；0.01-0.5 mg/kg；腹腔注射；第 6、10、13、16 和 21 天）有效抑制腹膜内卵巢肿瘤的生长。Ubamatamab（REGN4018；0.01-1 mg/kg；i.p；每周一次；总共五剂）显示血清细胞因子和 C 反应蛋白有轻微和短暂的增加，没有明显的毒性。Animal Model:NOD SCID gamma (NSG) mice injected with OVCAR-3/Luc cells
Dosage:0.01 mg/kg, 0.1 mg/kg, 0.5 mg/kg
Administration:i.p; on days 6, 10, 13, 16, and 21
Result:Significantly reduced tumor burden, and did not result in any changes in weight.
Animal Model:Cynomolgus monkeys
Dosage:0.01, 0.1, or 1 mg/kg
Administration:i.p; once a week; total of five doses
Result:Showed minimal and transient increases in serum cytokines and C-reactive protein.
体外研究：
Ubamatamab（REGN4018；0.1 pM-10 nM；48 小时）诱导人 T 细胞和猕猴 T 细胞杀死 OVCAR-3 细胞 (EC50 值分别为 13.6 pM 和 30.6 pM)。
Ubamatamab (REGN4018) is a humanized bispecific antibody targeted against Mucin 16 (MUC16) and CD3. Ubamatamab demonstrates potent antitumor activity.
体内研究：
Ubamatamab（REGN4018；0.01-0.5 mg/kg；腹腔注射；第 6、10、13、16 和 21 天）有效抑制腹膜内卵巢肿瘤的生长。Ubamatamab（REGN4018；0.01-1 mg/kg；i.p；每周一次；总共五剂）显示血清细胞因子和 C 反应蛋白有轻微和短暂的增加，没有明显的毒性。Animal Model:NOD SCID gamma (NSG) mice injected with OVCAR-3/Luc cells
Dosage:0.01 mg/kg, 0.1 mg/kg, 0.5 mg/kg
Administration:i.p; on days 6, 10, 13, 16, and 21
Result:Significantly reduced tumor burden, and did not result in any changes in weight.
Animal Model:Cynomolgus monkeys
Dosage:0.01, 0.1, or 1 mg/kg
Administration:i.p; once a week; total of five doses
Result:Showed minimal and transient increases in serum cytokines and C-reactive protein.
体外研究：
Ubamatamab（REGN4018；0.1 pM-10 nM；48 小时）诱导人 T 细胞和猕猴 T 细胞杀死 OVCAR-3 细胞 (EC50 值分别为 13.6 pM 和 30.6 pM)。
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备