产品
编 号：F751437
分子式：C22H19ClFN3O3
分子量：427.86
分子式：C22H19ClFN3O3
分子量：427.86
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规格
价格
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结构图
CAS No: 2351199-98-7
产品详情
生物活性：
IDO1-IN-7 is a highly potent and selective indoleamine-2,3-dioxygenase-1 (IDO1) inhibitor, with an IC50 of 6.1 nM in in the cellular assay (SKOV3). IDO1-IN-7 has immunomodulatory effects. IDO1-IN-7 can be used for the research of cancer.
体内研究：
IDO1-IN-7 (10 mg/kg; p.o.) shows Cmax=10.0 μM, AUC0-8 h=27.1 μM*h, t1/2=1.4 h in mouse.Animal Model:Mouse
Dosage:10 mg/kg (Pharmacokinetic Analysis)
Administration:Oral administration
Result:Cmax (10.0 μM), AUC0-8 h (27.1 μM*h), t1/2 (1.4 h)
体外研究：
IDO1-IN-7 exhibits moderate potency in a human whole blood assay with an IC50of 330 nM.IDO1-IN-7 shows a favorable profile such as good metabolic stability and acceptable off-target selectivity.IDO1-IN-7 shows a high selectivity for IDO1 over tryptophan 2,3-dioxygenase (TDO) (IC50=14,000 nM).
IDO1-IN-7 is a highly potent and selective indoleamine-2,3-dioxygenase-1 (IDO1) inhibitor, with an IC50 of 6.1 nM in in the cellular assay (SKOV3). IDO1-IN-7 has immunomodulatory effects. IDO1-IN-7 can be used for the research of cancer.
体内研究：
IDO1-IN-7 (10 mg/kg; p.o.) shows Cmax=10.0 μM, AUC0-8 h=27.1 μM*h, t1/2=1.4 h in mouse.Animal Model:Mouse
Dosage:10 mg/kg (Pharmacokinetic Analysis)
Administration:Oral administration
Result:Cmax (10.0 μM), AUC0-8 h (27.1 μM*h), t1/2 (1.4 h)
体外研究：
IDO1-IN-7 exhibits moderate potency in a human whole blood assay with an IC50of 330 nM.IDO1-IN-7 shows a favorable profile such as good metabolic stability and acceptable off-target selectivity.IDO1-IN-7 shows a high selectivity for IDO1 over tryptophan 2,3-dioxygenase (TDO) (IC50=14,000 nM).
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