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编 号:F751770
分子式:C18H11F4NO2
分子量:349.28
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10mM*1mL in DMSO
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1mg
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5mg
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10mg
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25mg
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生物活性:
VRK-IN-1 is a potent and selective inhibitor of vaccinia-related kinases 1 (VRK1), with an IC50 of 150 nM. VRK1 is human Ser/Thr protein kinases associated with increased cell division and neurological disorders.

体外研究:
VRK-IN-1 binds to VRK1-FL by enthalpy-driven, with a Kd of 190 nM.?VRK-IN-1 (0.4-25 μM; 24 h) slightly decreases the viability of human HeLa cells at the concentration of 3.2 μM.
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