产品
编 号：F752064
分子式：C28H24F2N4O2
分子量：486.51
分子式：C28H24F2N4O2
分子量：486.51
产品类型
规格
价格
是否有货
结构图
CAS No: 2404604-06-2
产品详情
生物活性：
ITK inhibitor 6 (compound 43) is a potent and selective ITK inhibitor with IC50s of 4 nM, 133 nM, 320 nM, 2360 nM, 155 nM for ITK, BTK, JAK3, EGFR, LCK, respectively. ITK inhibitor 6 inhibits phosphorylation of PLCγ1 and ERK1/2. ITK inhibitor 6 shows antiproliferative activities.
体外研究：
ITK inhibitor 6 (compound 43) shows antiproliferative activities with GI50s of 5.1, 3.7, 3.4, 5.4, 19 μM for Jurkat, Molt-4, CCRF-CEM, H9, HEK 293 T cells, respectively.ITK inhibitor 6 docks into the ATP-binding site of ITK and BTK.
ITK inhibitor 6 (compound 43) is a potent and selective ITK inhibitor with IC50s of 4 nM, 133 nM, 320 nM, 2360 nM, 155 nM for ITK, BTK, JAK3, EGFR, LCK, respectively. ITK inhibitor 6 inhibits phosphorylation of PLCγ1 and ERK1/2. ITK inhibitor 6 shows antiproliferative activities.
体外研究：
ITK inhibitor 6 (compound 43) shows antiproliferative activities with GI50s of 5.1, 3.7, 3.4, 5.4, 19 μM for Jurkat, Molt-4, CCRF-CEM, H9, HEK 293 T cells, respectively.ITK inhibitor 6 docks into the ATP-binding site of ITK and BTK.
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备