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编 号:F752320
分子式:C22H22N3Na2O8PS
分子量:565.44
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生物活性:
Anticancer agent 61 (compound 3v) is an orally active and potent anticancer agent. Anticancer agent 61 shows antiproliferative activity in HepG2, Bel-7402 and MCF-7 cancer cells, with IC50 values of 1.12, 1.97 and 1.08 μM, respectively. Anticancer agent 61 shows effective tumor growth inhibition.

体内研究:
Anticancer agent 61 (compound 3v) (BALB/c mice, 0-100 mg/kg, IV, once daily for 14 times) substantially reduces human HepG2 xenograft mouse tumor growth by 54.5% at 50 mg/kg.
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