产品
编 号:F752347
分子式:C23H21N7OS3
分子量:507.65
产品类型
结构图
CAS No: 2413565-19-0
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产品详情
生物活性:
COX-2-IN-26 is a potent, selective and orally active COX-2 inhibitor with IC50 values of 10.61, 0.067, 1.96 μM for COX-1, COX-2, 15-LOX, respectively. COX-2-IN-26 shows anti-inflammatory activity. COX-2-IN-26 shows gastrointestinal safety profile.
体内研究:
COX-2-IN-26 (28 μM/kg) shows a potent anti-inflammatory activity in rats with edema inhibition relative to indomethacin of 102% and 119% in 4h and 3h, respectively..COX-2-IN-26 (10, 30, 50 mg/kg; p.o.) shows GI safety profile with normal appearance for mucosa with intact surface epithelium and preserves glands but there is some congestion of the blood vessels in albino rats.
体外研究:
COX-2-IN-26 (compound 16) shows significant COX-2 selectivity with an SI value of 158.36.