产品
编 号：F752395
分子式：C33H39F3N4O6
分子量：644.68
分子式：C33H39F3N4O6
分子量：644.68
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CAS No: 2414240-89-2
产品详情
生物活性：
SMS2-IN-3 is a potent and selective SMS2inhibitor (IC50=2.2 nM), significantly reduces the hepatic SM (22:0) levels.
体内研究：
SMS2-IN-3 (37) has excellent SMS2 activity and high selectivity against SMS1. SMS2-IN-3 also reduces the level of SM by subcutaneous treatment.Animal Model:KK-Ay/Ta mice
Dosage:100, 200 mg/kg
Administration:SMS2-IN-3: s.c. (100, 200 mg/kg); p.o. (100, 200 mg/kg); once or twice per day for 7 days.
Result:cmpdCmax, (μg/mL) Tmax, (h) C24 h, (μg/mL)AUC0-24(μg?h/mL)MRT(h)
37(p.o.)6.50.830.007183.0
37(s.c.)0.708.00.23129.4
体外研究：
SMS2-IN-3 (37) is an excellent sphingomyelin synthase 2 inhibitor (SMS2). SMS2-IN-3 (37) has inhibition (IC50= 2.2 nM) and good selectivity against SMS1.
SMS2-IN-3 is a potent and selective SMS2inhibitor (IC50=2.2 nM), significantly reduces the hepatic SM (22:0) levels.
体内研究：
SMS2-IN-3 (37) has excellent SMS2 activity and high selectivity against SMS1. SMS2-IN-3 also reduces the level of SM by subcutaneous treatment.Animal Model:KK-Ay/Ta mice
Dosage:100, 200 mg/kg
Administration:SMS2-IN-3: s.c. (100, 200 mg/kg); p.o. (100, 200 mg/kg); once or twice per day for 7 days.
Result:cmpdCmax, (μg/mL) Tmax, (h) C24 h, (μg/mL)AUC0-24(μg?h/mL)MRT(h)
37(p.o.)6.50.830.007183.0
37(s.c.)0.708.00.23129.4
体外研究：
SMS2-IN-3 (37) is an excellent sphingomyelin synthase 2 inhibitor (SMS2). SMS2-IN-3 (37) has inhibition (IC50= 2.2 nM) and good selectivity against SMS1.
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