产品
编 号：F752728
分子式：C19H16FN5O2
分子量：365.36
分子式：C19H16FN5O2
分子量：365.36
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CAS No: 2435610-93-6
产品详情
生物活性：
PF-07059013 is an orally active and potent noncovalent modulator of sickled hemoglobin (HbS). PF-07059013 specifically binds to Hb with nanomolar affinity and displays strong partitioning into red blood cells (RBCs). PF-07059013 can be used for sickle cell disease (SCD) research.
体内研究：
PF-07059013 (10-490 mg/kg，口服灌胃，每日2次，连用2周) 显示 Townes SCD 小鼠的镰刀减少。Animal Model:Townes SCD mice (8-10 weeks old, male)
Dosage:10, 40, 200, and 490 mg/kg
Administration:Oral gavage, twice daily, for 2 weeks
Result:Showed a 37.8% (±9.0%) reduction in sickling at 200 mg/kg compared to vehicle treated mice.
PF-07059013 is an orally active and potent noncovalent modulator of sickled hemoglobin (HbS). PF-07059013 specifically binds to Hb with nanomolar affinity and displays strong partitioning into red blood cells (RBCs). PF-07059013 can be used for sickle cell disease (SCD) research.
体内研究：
PF-07059013 (10-490 mg/kg，口服灌胃，每日2次，连用2周) 显示 Townes SCD 小鼠的镰刀减少。Animal Model:Townes SCD mice (8-10 weeks old, male)
Dosage:10, 40, 200, and 490 mg/kg
Administration:Oral gavage, twice daily, for 2 weeks
Result:Showed a 37.8% (±9.0%) reduction in sickling at 200 mg/kg compared to vehicle treated mice.
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