产品
编 号：F753537
分子式：C26H32IN3
分子量：513.46
分子式：C26H32IN3
分子量：513.46
产品类型
规格
价格
是否有货
结构图
CAS No: 2516246-24-3
产品详情
生物活性：
FtsZ-IN-1 is a potent FtsZ inhibitor with quinolinium ring. FtsZ-IN-1 has stronger antibacterial activity against Gram-positive bacteria with MICs of 0.5-8 μg/mL. FtsZ-IN-1 significantly causes cell elongation of B. subtilis by enhancing FtsZ polymerization. FtsZ-IN-1 exhibits low hemolytic toxicity and low tendency to induce agent resistance. FtsZ-IN-1 has against drug-resistant bacteria activity.
体内研究：
FtsZ-IN-1 (1-64 μg/mL; 1 hour) exhibits low hemolytic toxicity in mice erythrocytes (from Kunming mice) with IC5 of 64 μg/mL.
体外研究：
FtsZ-IN-1 (compound A3) inhibits effectively the growth of S. aureus with MICs of 0.5-1 μg/mL, and generally displays less antibacterial potency against most Gram-negative bacteria tested such as E. coli ATCC 8739 (MIC = 64 μg/mL) and P. Aeruginosa ATCC 27853 (MIC >64 μg/mL).FtsZ-IN-1 exhibits MBCs of 4-8 μg/mL and MICs of 1-4 μg/mL against S. aureus, B. subtilis and E. faecium.FtsZ-IN-1 (0-24 μg/mL; 24 hours) inhibits the growth of S. aureus in a bacteriostatic mode at 1×, 2×, 4× MIC concentrations, and kills S. aureus at 8× MIC concentration.FtsZ-IN-1 can restore the antibacterial activity of methicillin against MRSA in a synergistic manner, with MIC of 2 μg/mL.FtsZ-IN-1 (2 μg/mL; 4 hours) can enlarge cell size of B. subtilis and inhibits bacterial cell division.FtsZ-IN-1 (0-15 μg/mL; 48 hours) exhibits IC50s of 12.77 and 9.42 μg/mL in L929 and HK-2 cells.FtsZ-IN-1 (2 μg/mL) can effectively delay the induction of drug resistance.In a Hemolytic activity assay, FtsZ-IN-1 (1-64 μg/mL; 1 hour) exhibits low hemolytic toxicity in mice erythrocytes (from Kunming mice) with IC5 of 64 μg/mL.
FtsZ-IN-1 is a potent FtsZ inhibitor with quinolinium ring. FtsZ-IN-1 has stronger antibacterial activity against Gram-positive bacteria with MICs of 0.5-8 μg/mL. FtsZ-IN-1 significantly causes cell elongation of B. subtilis by enhancing FtsZ polymerization. FtsZ-IN-1 exhibits low hemolytic toxicity and low tendency to induce agent resistance. FtsZ-IN-1 has against drug-resistant bacteria activity.
体内研究：
FtsZ-IN-1 (1-64 μg/mL; 1 hour) exhibits low hemolytic toxicity in mice erythrocytes (from Kunming mice) with IC5 of 64 μg/mL.
体外研究：
FtsZ-IN-1 (compound A3) inhibits effectively the growth of S. aureus with MICs of 0.5-1 μg/mL, and generally displays less antibacterial potency against most Gram-negative bacteria tested such as E. coli ATCC 8739 (MIC = 64 μg/mL) and P. Aeruginosa ATCC 27853 (MIC >64 μg/mL).FtsZ-IN-1 exhibits MBCs of 4-8 μg/mL and MICs of 1-4 μg/mL against S. aureus, B. subtilis and E. faecium.FtsZ-IN-1 (0-24 μg/mL; 24 hours) inhibits the growth of S. aureus in a bacteriostatic mode at 1×, 2×, 4× MIC concentrations, and kills S. aureus at 8× MIC concentration.FtsZ-IN-1 can restore the antibacterial activity of methicillin against MRSA in a synergistic manner, with MIC of 2 μg/mL.FtsZ-IN-1 (2 μg/mL; 4 hours) can enlarge cell size of B. subtilis and inhibits bacterial cell division.FtsZ-IN-1 (0-15 μg/mL; 48 hours) exhibits IC50s of 12.77 and 9.42 μg/mL in L929 and HK-2 cells.FtsZ-IN-1 (2 μg/mL) can effectively delay the induction of drug resistance.In a Hemolytic activity assay, FtsZ-IN-1 (1-64 μg/mL; 1 hour) exhibits low hemolytic toxicity in mice erythrocytes (from Kunming mice) with IC5 of 64 μg/mL.
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备