产品
编 号：F753669
分子式：C16H19NO3
分子量：273.33
分子式：C16H19NO3
分子量：273.33
产品类型
规格
价格
是否有货
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
50mg
询价
询价
结构图
CAS No: 254974-70-4
产品详情
生物活性：
hMAO-B/MB-COMT-IN-1 is a dual MAO-B/MB-COMT inhibitor (IC50s: 2.5 μΜ for hMAO-B, 3.84 μΜ for MB-COMT). hMAO-B/MB-COMT-IN-1 protects cells against oxidative damage. hMAO-B/MB-COMT-IN-1 can be used in the research of neurodegeneration disease, such as Parkinson’s Disease (PD).
体外研究：
hMAO-B/MB-COMT-IN-1 (compound 3, 50 μM, 24 h) decreases in resazurin reduction in differentiated SH-SY5Y cells.hMAO-B/MB-COMT-IN-1 (50 μM, 24 h) displays lysosomal toxicity by producing ROS in differentiated SH-SY5Y cells.hMAO-B/MB-COMT-IN-1 (10 μM, 30 min) displays remarkable cytoprotective effects against t-BHP in differentiated SH-SY5Y cells.hMAO-B/MB-COMT-IN-1 is predicted to cross the blood-brain barrier (BBB) by passive diffusion, determined by the parallel artificial membrane permeability assay (PAMPA)-BBB kit.
hMAO-B/MB-COMT-IN-1 is a dual MAO-B/MB-COMT inhibitor (IC50s: 2.5 μΜ for hMAO-B, 3.84 μΜ for MB-COMT). hMAO-B/MB-COMT-IN-1 protects cells against oxidative damage. hMAO-B/MB-COMT-IN-1 can be used in the research of neurodegeneration disease, such as Parkinson’s Disease (PD).
体外研究：
hMAO-B/MB-COMT-IN-1 (compound 3, 50 μM, 24 h) decreases in resazurin reduction in differentiated SH-SY5Y cells.hMAO-B/MB-COMT-IN-1 (50 μM, 24 h) displays lysosomal toxicity by producing ROS in differentiated SH-SY5Y cells.hMAO-B/MB-COMT-IN-1 (10 μM, 30 min) displays remarkable cytoprotective effects against t-BHP in differentiated SH-SY5Y cells.hMAO-B/MB-COMT-IN-1 is predicted to cross the blood-brain barrier (BBB) by passive diffusion, determined by the parallel artificial membrane permeability assay (PAMPA)-BBB kit.
产品资料
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