产品
编 号：F754282
分子式：C17H13N3O4
分子量：323.3
分子式：C17H13N3O4
分子量：323.3
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
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1mg
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5mg
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10mg
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25mg
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50mg
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100mg
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结构图
CAS No: 2642394-38-3
产品详情
生物活性：
Mtb ATP synthase-IN-1 (compound 6ab) is a potent Mycobacterium tuberculosis (Mtb) ATP synthase inhibitor, with MIC of 0.452-0.499 μg/mL against Mtb. Mtb ATP synthase-IN-1 has good metabolic stability, low cytotoxicity (Vero IC50 > 64 μg/mL), and acceptable oral bioavailability. Mtb ATP synthase-IN-1 can be used for researching anti-mycobacterium.
体内研究：
Mtb ATP synthase-IN-1 (50 mg/kg for PO, 5 mg/kg for IV; single dosage) exhibits good metabolic stability and acceptable oral bioavailability.Pharmacokinetic Parameters of Mtb ATP synthase-IN-1 in male CD-1 mouse.PO (50 mg/kg) IV (5 mg/kg)
Cmax (ng/mL)13331241
Tmax (h)0.83
T1/2 (h)0.510.33
AUC0-t (ng/mL·h)21971667
AUC0-∞ (ng/mL·h)21981672
MRT0-∞ (ng/mL)1.360.28
CL (mL/min/kg)51.4
F (%)13.1
Animal Model:Male CD-1 mouse
Dosage:50 and 5 mg/kg
Administration:50 mg/kg for PO, 5 mg/kg for IV; single dosage (Pharmacokinetics Analysis)
Result:Exhibited good metabolic stability and acceptable oral bioavailability.
Mtb ATP synthase-IN-1 (compound 6ab) is a potent Mycobacterium tuberculosis (Mtb) ATP synthase inhibitor, with MIC of 0.452-0.499 μg/mL against Mtb. Mtb ATP synthase-IN-1 has good metabolic stability, low cytotoxicity (Vero IC50 > 64 μg/mL), and acceptable oral bioavailability. Mtb ATP synthase-IN-1 can be used for researching anti-mycobacterium.
体内研究：
Mtb ATP synthase-IN-1 (50 mg/kg for PO, 5 mg/kg for IV; single dosage) exhibits good metabolic stability and acceptable oral bioavailability.Pharmacokinetic Parameters of Mtb ATP synthase-IN-1 in male CD-1 mouse.PO (50 mg/kg) IV (5 mg/kg)
Cmax (ng/mL)13331241
Tmax (h)0.83
T1/2 (h)0.510.33
AUC0-t (ng/mL·h)21971667
AUC0-∞ (ng/mL·h)21981672
MRT0-∞ (ng/mL)1.360.28
CL (mL/min/kg)51.4
F (%)13.1
Animal Model:Male CD-1 mouse
Dosage:50 and 5 mg/kg
Administration:50 mg/kg for PO, 5 mg/kg for IV; single dosage (Pharmacokinetics Analysis)
Result:Exhibited good metabolic stability and acceptable oral bioavailability.
产品资料
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