产品
编 号：F754415
分子式：C15H13ClF2N4O3S2
分子量：434.87
分子式：C15H13ClF2N4O3S2
分子量：434.87
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 2653254-31-8
产品详情
生物活性：
TYA-018 is an orally active, potent and highly selective HDAC6 inhibitor. TYA-018 can protect heart function in mice. TYA-018 also enhances energetics in mice by increasing expression of targets associated with fatty acid metabolism, protein metabolism, and oxidative phosphorylation.
体内研究：
TYA-018 (15 mg/kg，口服强饲法，每天，持续 8 周)可防止 BAG3cKO 小鼠中的肌节损伤，降低 Nppb 表达 。Animal Model:BAG3cKO mice
Dosage:15 mg/kg
Administration:Oral gavage, daily, starting at 2 months old, for 8 weeks
Result:Conferred cardioprotection in mice. Significantly reduced Nppb expression to near WT. Reduced fibrosis in BAG3cKO mice, albeit not significantly. partially restored protein expression of FLNC, PINK1, VDAC2, and p62 to amounts similar to WT mice. Significantly reduced the percentage of cardiomyocytes with damaged and reduced sarcomeres in BAG3cKO mice. Significantly reduced mitochondrial content to amounts similar to WT mice.
TYA-018 is an orally active, potent and highly selective HDAC6 inhibitor. TYA-018 can protect heart function in mice. TYA-018 also enhances energetics in mice by increasing expression of targets associated with fatty acid metabolism, protein metabolism, and oxidative phosphorylation.
体内研究：
TYA-018 (15 mg/kg，口服强饲法，每天，持续 8 周)可防止 BAG3cKO 小鼠中的肌节损伤，降低 Nppb 表达 。Animal Model:BAG3cKO mice
Dosage:15 mg/kg
Administration:Oral gavage, daily, starting at 2 months old, for 8 weeks
Result:Conferred cardioprotection in mice. Significantly reduced Nppb expression to near WT. Reduced fibrosis in BAG3cKO mice, albeit not significantly. partially restored protein expression of FLNC, PINK1, VDAC2, and p62 to amounts similar to WT mice. Significantly reduced the percentage of cardiomyocytes with damaged and reduced sarcomeres in BAG3cKO mice. Significantly reduced mitochondrial content to amounts similar to WT mice.
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