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编 号:F754501
分子式:C46H28N10O8Si
分子量:876.86
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生物活性:
Mal-Pc is a versatile molecular photosensitizer designed based phthalocyanine and maleimides. Mal-Pc can react with GSH to deplete GSH and reduce aggregation, thereby improving ROS (Reactive Oxygen Species)-mediated effect of photodynamic therapy (PDT) in cancer cells.

体外研究:
Having two maleimide axial substituents, Mal-Pc exhibits faster accumulation in cancer cells and then can react with GSH to deplete GSH and reduce aggregation, thereby improving ROS-mediated anticancer effect of PDT. The fluorescence imaging demonstrated that Mal-Pc eliminate from normal cells faster due to the highly hydrophilic reaction product.
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