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编 号：F755135
分子式：C18H13N5O3
分子量：347.33
分子式：C18H13N5O3
分子量：347.33
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CAS No: 2738381-47-8
产品详情
生物活性：
Anti-infective agent 5 (compound 74) is an orally active inhibitor of Trypanosoma cruzi with an IC50 value of 0.10 μM. Anti-infective agent 5 effectively reduces parasite burden in vivo. Anti-infective agent 5 can be used for the research of infection.
体内研究：
Anti-infective agent 5 (50 mg/kg; p.o. twice daily for five days) reduces the parasite burden in bioluminescent T. cruzi mouse model.Animal Model:BALB/c mice with bioluminescent T. cruzi CL Brener parasites infection
Dosage:50 mg/kg
Administration:Oral gavage; 50 mg/kg twice daily for five days
Result:Showed a reduction in parasite burden of >98-99% with no significant adverse effects observed in mice.
体外研究：
Anti-infective agent 5 (0.1 nM-100 μM; 48 h) shows antitrypanosomal activity against T. cruzi amastigotes in 3T3 cells with an IC50 value of 0.10 μM.
Anti-infective agent 5 (compound 74) is an orally active inhibitor of Trypanosoma cruzi with an IC50 value of 0.10 μM. Anti-infective agent 5 effectively reduces parasite burden in vivo. Anti-infective agent 5 can be used for the research of infection.
体内研究：
Anti-infective agent 5 (50 mg/kg; p.o. twice daily for five days) reduces the parasite burden in bioluminescent T. cruzi mouse model.Animal Model:BALB/c mice with bioluminescent T. cruzi CL Brener parasites infection
Dosage:50 mg/kg
Administration:Oral gavage; 50 mg/kg twice daily for five days
Result:Showed a reduction in parasite burden of >98-99% with no significant adverse effects observed in mice.
体外研究：
Anti-infective agent 5 (0.1 nM-100 μM; 48 h) shows antitrypanosomal activity against T. cruzi amastigotes in 3T3 cells with an IC50 value of 0.10 μM.
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