产品
编 号：F755707
分子式：C24H19BrN2O8S
分子量：575.39
分子式：C24H19BrN2O8S
分子量：575.39
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CAS No: 2763621-91-4
产品详情
生物活性：
Antitumor agent-42 (Compound 15h) is a bifunctional agent exhibiting both tubulin polymerized inhibition and NO-releasing activities, resulting in potent anti-angiogenesis, colony formation inhibition, cell cycle arrest and apoptosis induction effects.
体内研究：
In the nude mice xenograft model, antitumor agent-42 significantly inhibited the paclitaxel-resistant tumor growth with low toxicity.
体外研究：
Antitumor agent-42 (Compound 15h) is a potent antitumor agent, which towards A2780, MDA-MB-231, HCT-116 and A549 cells with IC50 values of 0.012, 0.015, 0.011 and 0.008 μM, respectively.
Antitumor agent-42 (Compound 15h) is a bifunctional agent exhibiting both tubulin polymerized inhibition and NO-releasing activities, resulting in potent anti-angiogenesis, colony formation inhibition, cell cycle arrest and apoptosis induction effects.
体内研究：
In the nude mice xenograft model, antitumor agent-42 significantly inhibited the paclitaxel-resistant tumor growth with low toxicity.
体外研究：
Antitumor agent-42 (Compound 15h) is a potent antitumor agent, which towards A2780, MDA-MB-231, HCT-116 and A549 cells with IC50 values of 0.012, 0.015, 0.011 and 0.008 μM, respectively.
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