产品
编 号：F755946
分子式：C48H58ClFN8O12
分子量：993.47
分子式：C48H58ClFN8O12
分子量：993.47
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CAS No: 2772613-37-1
产品详情
生物活性：
MS9427 is a potent PROTAC EGFR degrader with Kds of 7.1 nM and 4.3 nM for EGFR WT and EGFR L858R, respectively. MS9427 selectively degrades the mutant but not the WT EGFR through both the ubiquitin/proteasome system (UPS) and autophagy/lysosome pathways. MS9427 potently inhibits the proliferation of NSCLC cells. MS9427 can be used for researching anticancer.
体外研究：
MS9427 对 HCC-827 细胞具有抗增殖活性，GI50 为 0.87 ± 0.27 μM 。MS9427 (0-10μM, 16 h) 有效诱导 EGFRdel19降解 (DC50=82 ± 73 nM)，并在 HCC-827 细胞中以浓度依赖的方式抑制EGFR磷酸化(p-EGFR)。
MS9427 is a potent PROTAC EGFR degrader with Kds of 7.1 nM and 4.3 nM for EGFR WT and EGFR L858R, respectively. MS9427 selectively degrades the mutant but not the WT EGFR through both the ubiquitin/proteasome system (UPS) and autophagy/lysosome pathways. MS9427 potently inhibits the proliferation of NSCLC cells. MS9427 can be used for researching anticancer.
体外研究：
MS9427 对 HCC-827 细胞具有抗增殖活性，GI50 为 0.87 ± 0.27 μM 。MS9427 (0-10μM, 16 h) 有效诱导 EGFRdel19降解 (DC50=82 ± 73 nM)，并在 HCC-827 细胞中以浓度依赖的方式抑制EGFR磷酸化(p-EGFR)。
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