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编 号：F755955
分子式：C30H32N2O6
分子量：516.58
分子式：C30H32N2O6
分子量：516.58
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CAS No: 2773408-33-4
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生物活性：
Antimalarial agent 16 (Compound 4h) is a parasite inhibitor. Antimalarial agent 16 shows antimalarial activity, and can inhibit P. falciparum parasite growth (IC50=2.0 nM).
体内研究：
Antimalarial agent 16 (i.p.; 40 or 200 mg/kg; once daily; 4 days) exhibits significant in vivo antimalarial effects.Animal Model:Plasmodium berghei (P. berghei) ANKA infected ICR mouse
Dosage:40 or 200 mg/kg
Administration:Intraperitoneal injection; 40 or 200 mg/kg; once daily; 4 days
Result:Inhibited malaria parasite growth effectively and retained parasitemia levels until day 8 post-infection at a dose of 40 mg/kg, attenuated parasitemia levels until day 8.Maintained survival rates until day 11 post-infection, but the rates decreased rapidly after day 11 at a dose of 40 mg/kg, observed a significant enhancement in survival a dose of 200 mg/kg.
Antimalarial agent 16 (Compound 4h) is a parasite inhibitor. Antimalarial agent 16 shows antimalarial activity, and can inhibit P. falciparum parasite growth (IC50=2.0 nM).
体内研究：
Antimalarial agent 16 (i.p.; 40 or 200 mg/kg; once daily; 4 days) exhibits significant in vivo antimalarial effects.Animal Model:Plasmodium berghei (P. berghei) ANKA infected ICR mouse
Dosage:40 or 200 mg/kg
Administration:Intraperitoneal injection; 40 or 200 mg/kg; once daily; 4 days
Result:Inhibited malaria parasite growth effectively and retained parasitemia levels until day 8 post-infection at a dose of 40 mg/kg, attenuated parasitemia levels until day 8.Maintained survival rates until day 11 post-infection, but the rates decreased rapidly after day 11 at a dose of 40 mg/kg, observed a significant enhancement in survival a dose of 200 mg/kg.
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