产品
编 号：F078967
分子式：C14H19IN2O3
分子量：390.22
分子式：C14H19IN2O3
分子量：390.22
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CAS No: 1219807-87-0
产品详情
生物活性：
4-Iodo-SAHA (1k) is an orally active class I and class II histone deacetylase (HDAC) inhibitor with EC50s of 1.1, 0.95, 0.12, 0.24, 0.85 and 1.3 μM for Skbr3, HT29, U937, JA16 and HL60 cell lines, respectively. 4-Iodo-SAHA (1k) can be used for the research of cancer.
体内研究：
4-Iodo-SAHA (1k) (50 mg/kg; p.o. five times a week for two weeks) compares to SAHA-treated and control mice with similar toxicity.Animal Model:8-week-old fvb mice
Dosage:50 mg/kg
Administration:Oral gavage; 50 mg/kg five times per week; for 2 weeks
Result:Compared to both SAHA-treated and control mice with similar body weights and hematological counts.
体外研究：
4-Iodo-SAHA (0.1-100 μM; 48 h) inhibits Skbr3, HT29, U937, JA16 and HL60 cell lines .4-Iodo-SAHA (2 μM; 6-24 h) affects acetylated H4 and p21 levels in SKBR3 cells.
4-Iodo-SAHA (1k) is an orally active class I and class II histone deacetylase (HDAC) inhibitor with EC50s of 1.1, 0.95, 0.12, 0.24, 0.85 and 1.3 μM for Skbr3, HT29, U937, JA16 and HL60 cell lines, respectively. 4-Iodo-SAHA (1k) can be used for the research of cancer.
体内研究：
4-Iodo-SAHA (1k) (50 mg/kg; p.o. five times a week for two weeks) compares to SAHA-treated and control mice with similar toxicity.Animal Model:8-week-old fvb mice
Dosage:50 mg/kg
Administration:Oral gavage; 50 mg/kg five times per week; for 2 weeks
Result:Compared to both SAHA-treated and control mice with similar body weights and hematological counts.
体外研究：
4-Iodo-SAHA (0.1-100 μM; 48 h) inhibits Skbr3, HT29, U937, JA16 and HL60 cell lines .4-Iodo-SAHA (2 μM; 6-24 h) affects acetylated H4 and p21 levels in SKBR3 cells.
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