产品
编 号：F756131
分子式：C21H21N5O5S
分子量：455.49
分子式：C21H21N5O5S
分子量：455.49
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CAS No: 2816165-16-7
产品详情
生物活性：
SARS-CoV-2 nsp14-IN-2 is a potent SARS-CoV-2 Nsp14 methyltransferase inhibitor with an IC50 value of 0.093 μM. SARS-CoV-2 nsp14-IN-2 shows antiviral activity. SARS-CoV-2 nsp14-IN-2 shows plasma and liver S9 stability. SARS-CoV-2 nsp14-IN-2 has the potential for the research of COVID-19.
体外研究：
SARS-CoV-2 nsp14-IN-2 (compound 10) (0-100 μM) shows antiviral activity with an EC50 value of 0.72 μM and CC50 value of >100 μM.SARS-CoV-2 nsp14-IN-2 (24 h) shows plasma stability with t1/2s of >24, >24 h for human and mouse, respectively.SARS-CoV-2 nsp14-IN-2 (45 min) shows liver S9 stability with t1/2 values of 842 min and >45 min in Phase I and phase II in human liver, respectively; and t1/2 values of 28.9 min and >45 min in Phase I and phase II in mouse liver, respectively.
SARS-CoV-2 nsp14-IN-2 is a potent SARS-CoV-2 Nsp14 methyltransferase inhibitor with an IC50 value of 0.093 μM. SARS-CoV-2 nsp14-IN-2 shows antiviral activity. SARS-CoV-2 nsp14-IN-2 shows plasma and liver S9 stability. SARS-CoV-2 nsp14-IN-2 has the potential for the research of COVID-19.
体外研究：
SARS-CoV-2 nsp14-IN-2 (compound 10) (0-100 μM) shows antiviral activity with an EC50 value of 0.72 μM and CC50 value of >100 μM.SARS-CoV-2 nsp14-IN-2 (24 h) shows plasma stability with t1/2s of >24, >24 h for human and mouse, respectively.SARS-CoV-2 nsp14-IN-2 (45 min) shows liver S9 stability with t1/2 values of 842 min and >45 min in Phase I and phase II in human liver, respectively; and t1/2 values of 28.9 min and >45 min in Phase I and phase II in mouse liver, respectively.
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