产品
编 号：F756145
分子式：C23H27ClF3N5O5
分子量：545.94
分子式：C23H27ClF3N5O5
分子量：545.94
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CAS No: 2819700-92-8
产品详情
生物活性：
PARP7-IN-12 is a potent PARP7 Inhibitor with an IC50 value of 7.836 nM. PARP7-IN-12 can be used in research of cancer.
体内研究：
PARP7-IN-12 (compound 85A; 3 and 100 mg/kg; i.v. and p.o.; Balb/c mice) has good pharmacokinetic property.Animal Model:Balb/c mice
Dosage:3 and 100 mg/kg
Administration:Intravenous injection (3 mg/kg) and oral administration (10 mg/kg)
Result:1.19 Administrationi.v. (3 mg/kg)p.o. (100 mg/kg)
CL (mL/min/kg)32
Vss (L/kg)0.4
Cmax (ng/mL)21733
AUClast (ng·h/mL)26442
Oral BA (F%)48
体外研究：
PARP7-IN-12 (compound 85A; 16-24 h) inhibits cell proliferative with an IC50 values of 20.722 nM in H1373 cells.
PARP7-IN-12 is a potent PARP7 Inhibitor with an IC50 value of 7.836 nM. PARP7-IN-12 can be used in research of cancer.
体内研究：
PARP7-IN-12 (compound 85A; 3 and 100 mg/kg; i.v. and p.o.; Balb/c mice) has good pharmacokinetic property.Animal Model:Balb/c mice
Dosage:3 and 100 mg/kg
Administration:Intravenous injection (3 mg/kg) and oral administration (10 mg/kg)
Result:1.19 Administrationi.v. (3 mg/kg)p.o. (100 mg/kg)
CL (mL/min/kg)32
Vss (L/kg)0.4
Cmax (ng/mL)21733
AUClast (ng·h/mL)26442
Oral BA (F%)48
体外研究：
PARP7-IN-12 (compound 85A; 16-24 h) inhibits cell proliferative with an IC50 values of 20.722 nM in H1373 cells.
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