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编 号:F756149
分子式:C16H15ClN2O
分子量:286.76
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生物活性:
PBRM1-BD2-IN-6 is a potent PBRM1 bromodomain inhibitor with an IC50 value of 0.22 μM. PBRM1-BD2-IN-6 shows antiproliferation activity. PBRM1-BD2-IN-6 has the potential for the research of PBRM1-dependent cancer.

体外研究:
PBRM1-BD2-IN-6 (compound 25) (0.1, 1, 10 μM; 5 days) shows antiproliferation activity with IC50 values of 0.66, 0.77, 0.32 μM for LNCaP, PC3, HEK293T cells, respectively.
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