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编 号：F756157
分子式：C45H47NO13
分子量：809.85
分子式：C45H47NO13
分子量：809.85
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CAS No: 2820146-10-7
产品详情
生物活性：
Antitumor agent-67 (compound 3) is a potent antitumor agent. Antitumor agent-67 has highly selective toxicity to cancer cells and lower damage to normal cells. Antitumor agent-67 can be activated by NQO1 and effectively liberate podophyllotoxin and kill tumor cells. Antitumor agent-67 significantly suppresses cancer growth in HepG2 xenograft models without obvious toxicity.
体外研究：
Antitumor agent-67 (compound 3) has antiproliferative activity against HepG2, A549, LO2, HepG2/Hyp, A549/Hyp and A549/T with IC50s of 84 ± 9 μM, 100 ± 19 μM, 312 ± 34 μM, 113 ± 13 μM, 185 ± 24 μM and 197 ± 29 μM.
Antitumor agent-67 (compound 3) is a potent antitumor agent. Antitumor agent-67 has highly selective toxicity to cancer cells and lower damage to normal cells. Antitumor agent-67 can be activated by NQO1 and effectively liberate podophyllotoxin and kill tumor cells. Antitumor agent-67 significantly suppresses cancer growth in HepG2 xenograft models without obvious toxicity.
体外研究：
Antitumor agent-67 (compound 3) has antiproliferative activity against HepG2, A549, LO2, HepG2/Hyp, A549/Hyp and A549/T with IC50s of 84 ± 9 μM, 100 ± 19 μM, 312 ± 34 μM, 113 ± 13 μM, 185 ± 24 μM and 197 ± 29 μM.
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