产品
编 号：F756391
分子式：C29H32N6O2S
分子量：528.67
分子式：C29H32N6O2S
分子量：528.67
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CAS No: 2857112-06-0
产品详情
生物活性：
PF-6870961 is an inverse agonist of GHSR1a with Ki values of 73.6 nM (human GHSR), 239 nM (rat GHSR), and 217 nM (dog GHSR), respectively. PF-6870961 inhibits the constitutive GHSR1a-induced IP accumulation with an IC50 value of 300 nM. PF-6870961 also inhibits constitutive GHSR1a β-arrestin mobilization with an IC50 value of 1.10 nM.
体内研究：
PF-6870961 (40 mg/kg; i.p.) suppresses food intake in both satiated and fasted rats.Animal Model:Satiated and fasted rats model
Dosage:2.5 mg/kg, 10 mg/kg, and 40 mg/kg
Administration:Intraperitoneal injection
Result:Significantly reduced food intake at 40 mg/kg.
PF-6870961 is an inverse agonist of GHSR1a with Ki values of 73.6 nM (human GHSR), 239 nM (rat GHSR), and 217 nM (dog GHSR), respectively. PF-6870961 inhibits the constitutive GHSR1a-induced IP accumulation with an IC50 value of 300 nM. PF-6870961 also inhibits constitutive GHSR1a β-arrestin mobilization with an IC50 value of 1.10 nM.
体内研究：
PF-6870961 (40 mg/kg; i.p.) suppresses food intake in both satiated and fasted rats.Animal Model:Satiated and fasted rats model
Dosage:2.5 mg/kg, 10 mg/kg, and 40 mg/kg
Administration:Intraperitoneal injection
Result:Significantly reduced food intake at 40 mg/kg.
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