产品
编 号：F756488
分子式：C32H33F3N8O5
分子量：666.65
分子式：C32H33F3N8O5
分子量：666.65
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 2869954-53-8
产品详情
生物活性：
Werner syndrome RecQ helicase-IN-4 is a potent and orally active werner syndrome recQ helicase (WRN) inhibitor with an IC50 value of 0.06 μM. Werner syndrome RecQ helicase-IN-4 shows antiproliferative activity. Werner syndrome RecQ helicase-IN-4 shows anticancer activity.
体内研究：
Werner syndrome RecQ helicase-IN-4 (240 mg/kg; daily for 18 days) 在小鼠体内显示出抗癌活性。Animal Model:Female Crl:NU(NCr)-Foxn1nu -Homozygous nude mice (SW48 xenografts cells)
Dosage:240 mg/kg
Administration:P.o.; daily for 18 days
Result:Inhibited tumor growth.
体外研究：
Werner syndrome RecQ helicase-IN-4 (example 58) (0-10 μM; 8-20 days) 显示抗增殖活性，对 SW48，DLD1 WRN-KO 细胞的 GI50s 值分别为 0.07，>10 μM。
Werner syndrome RecQ helicase-IN-4 is a potent and orally active werner syndrome recQ helicase (WRN) inhibitor with an IC50 value of 0.06 μM. Werner syndrome RecQ helicase-IN-4 shows antiproliferative activity. Werner syndrome RecQ helicase-IN-4 shows anticancer activity.
体内研究：
Werner syndrome RecQ helicase-IN-4 (240 mg/kg; daily for 18 days) 在小鼠体内显示出抗癌活性。Animal Model:Female Crl:NU(NCr)-Foxn1nu -Homozygous nude mice (SW48 xenografts cells)
Dosage:240 mg/kg
Administration:P.o.; daily for 18 days
Result:Inhibited tumor growth.
体外研究：
Werner syndrome RecQ helicase-IN-4 (example 58) (0-10 μM; 8-20 days) 显示抗增殖活性，对 SW48，DLD1 WRN-KO 细胞的 GI50s 值分别为 0.07，>10 μM。
产品资料
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