产品
编 号：F756551
分子式：C32H39N3O
分子量：481.67
分子式：C32H39N3O
分子量：481.67
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CAS No: 2878598-59-3
产品详情
生物活性：
Cav 3.2 inhibitor 1 is a T-type calcium channel inhibitor with little binding affinity to dopamine D2 receptors. Cav 3.2 inhibitor 1 can be used for the research of somatic and visceral pain.
体内研究：
Cav 3.2 inhibitor 1 (compound 3a, 10 mg/kg, i.p.) suppresses Cav3.2-dependent somatic and visceral pain in mice.Cav 3.2 inhibitor 1 (8 nmol/mouse, i.c.v.) has no effect on long-lasting catalepsy in mice.Animal Model:Colonic pain and referred hyperalgesia mice induced by intracolonic (i.col.) administration of Na2S at 5 nmol/mouse.
Dosage:1-10 mg/kg
Administration:Intraperitoneal injection (i.p.)
Result:Completely blocked the Na2S-induced colonic pain and referred hyperalgesia.
体外研究：
Cav 3.2 inhibitor 1 (compound 3a, 0.3 μM) inhibits Cav3.2 activities by about 50% in Cav3.2-transfected HEK293 cells.Cav 3.2 inhibitor 1 (1 and 10 μM) displays little binding affinity to D2 receptors.Cav 3.2 inhibitor 1 (0.01-1 μM) inhibits T-currents in Cav3.1-expressing HEK293 cells.
Cav 3.2 inhibitor 1 is a T-type calcium channel inhibitor with little binding affinity to dopamine D2 receptors. Cav 3.2 inhibitor 1 can be used for the research of somatic and visceral pain.
体内研究：
Cav 3.2 inhibitor 1 (compound 3a, 10 mg/kg, i.p.) suppresses Cav3.2-dependent somatic and visceral pain in mice.Cav 3.2 inhibitor 1 (8 nmol/mouse, i.c.v.) has no effect on long-lasting catalepsy in mice.Animal Model:Colonic pain and referred hyperalgesia mice induced by intracolonic (i.col.) administration of Na2S at 5 nmol/mouse.
Dosage:1-10 mg/kg
Administration:Intraperitoneal injection (i.p.)
Result:Completely blocked the Na2S-induced colonic pain and referred hyperalgesia.
体外研究：
Cav 3.2 inhibitor 1 (compound 3a, 0.3 μM) inhibits Cav3.2 activities by about 50% in Cav3.2-transfected HEK293 cells.Cav 3.2 inhibitor 1 (1 and 10 μM) displays little binding affinity to D2 receptors.Cav 3.2 inhibitor 1 (0.01-1 μM) inhibits T-currents in Cav3.1-expressing HEK293 cells.
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