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编 号：F756552
分子式：C32H37N3O2
分子量：495.66
分子式：C32H37N3O2
分子量：495.66
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CAS No: 2878598-69-5
产品详情
生物活性：
Cav 3.2 inhibitor 3 (Compound 4) is a potent Cav3.2 T-type Ca2+ channel inhibitor with an IC50 of 0.1534 μM, and has little binding affinity to D2 receptors.
体内研究：
Cav 3.2 inhibitor 3 (Compound 4) (1-10 mg/kg; i.p.; once) potently suppresses T-channel-dependent somatic and visceral pain in mice.Animal Model:C57BL/6J mice, Cav3.2-dependent somatic and visceral pain model
Dosage:1, 3 and 10 mg/kg
Administration:Intraperitoneal administration, once
Result:Reduced the mechanical allodynia in the hindpaw and colonic pain/referred hyperalgesia following i.pl. and i.col. administrations of Na2S, a donor of H2S, respectively. Suppressed the i.pl. Na2S-induced paw allodynia in a dose-dependent manner, and the maximally effective doses were roughly estimated at 10 mg/kg.
Cav 3.2 inhibitor 3 (Compound 4) is a potent Cav3.2 T-type Ca2+ channel inhibitor with an IC50 of 0.1534 μM, and has little binding affinity to D2 receptors.
体内研究：
Cav 3.2 inhibitor 3 (Compound 4) (1-10 mg/kg; i.p.; once) potently suppresses T-channel-dependent somatic and visceral pain in mice.Animal Model:C57BL/6J mice, Cav3.2-dependent somatic and visceral pain model
Dosage:1, 3 and 10 mg/kg
Administration:Intraperitoneal administration, once
Result:Reduced the mechanical allodynia in the hindpaw and colonic pain/referred hyperalgesia following i.pl. and i.col. administrations of Na2S, a donor of H2S, respectively. Suppressed the i.pl. Na2S-induced paw allodynia in a dose-dependent manner, and the maximally effective doses were roughly estimated at 10 mg/kg.
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