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编 号：F081055
分子式：C21H17BrFN3O4S
分子量：506.34
分子式：C21H17BrFN3O4S
分子量：506.34
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CAS No: 1222878-02-5
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生物活性：
ML169 (VU0405652) is a potent, selective and brain penetrant positive allosteric modulator (PAM) of M1 mAChR, with an EC50 of 1.38 μM. ML169 is a MLPCN probe and can be used for Alzheimer’s disease.
体内研究：
ML169 (VU0405652) (10 mg/kg; i.p.) affords a brainAUC/plasmaAUC of 0.32 at 1 h in rats.
体外研究：
ML169 (VU0405652) is selective versus the biogenic amines (D2, H-HT2B, etc...) and displays no orthosteric binding at M1–M5.ML169 shifts APP processing towards a non-amyloidogenic pathway.ML169 (2 μM) potentiates the carbachol (CCh)-mediated non-amyloidogenic APPsa release to the same degree as 10 μM CCh.
ML169 (VU0405652) is a potent, selective and brain penetrant positive allosteric modulator (PAM) of M1 mAChR, with an EC50 of 1.38 μM. ML169 is a MLPCN probe and can be used for Alzheimer’s disease.
体内研究：
ML169 (VU0405652) (10 mg/kg; i.p.) affords a brainAUC/plasmaAUC of 0.32 at 1 h in rats.
体外研究：
ML169 (VU0405652) is selective versus the biogenic amines (D2, H-HT2B, etc...) and displays no orthosteric binding at M1–M5.ML169 shifts APP processing towards a non-amyloidogenic pathway.ML169 (2 μM) potentiates the carbachol (CCh)-mediated non-amyloidogenic APPsa release to the same degree as 10 μM CCh.
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