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编 号：F757005
分子式：C26H23NO6
分子量：445.46
分子式：C26H23NO6
分子量：445.46
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CAS No: 2929239-84-7
产品详情
生物活性：
LTB4 antagonist 1, a carboxamide-acid compound, is a potent Leukotriene B4 (LTB4) antagonist with an IC50 of 288 nM. LTB4 antagonist 1 has significant anti-inflammatory properties.
体内研究：
LTB4 antagonist 1 (化合物 24b; 30 mg/kg; 口服) 在大鼠角叉菜胶足足水肿模型中，给药 1 小时后具有显着的抗炎活性。Animal Model:The model of podal edema with carrageenan in rats
Dosage:30 mg/kg
Administration:Orally; single dose
Result:After 1 h, a significant anti-inflammatory activity was observed (percentage inhibition of the edema: 39.7%) on carrageenan compared to the control group. After 2 h, the anti-inflammatory activity decreases sharply (16.2%). This activity completely disappeared after 4 h under TUKEY test.
LTB4 antagonist 1, a carboxamide-acid compound, is a potent Leukotriene B4 (LTB4) antagonist with an IC50 of 288 nM. LTB4 antagonist 1 has significant anti-inflammatory properties.
体内研究：
LTB4 antagonist 1 (化合物 24b; 30 mg/kg; 口服) 在大鼠角叉菜胶足足水肿模型中，给药 1 小时后具有显着的抗炎活性。Animal Model:The model of podal edema with carrageenan in rats
Dosage:30 mg/kg
Administration:Orally; single dose
Result:After 1 h, a significant anti-inflammatory activity was observed (percentage inhibition of the edema: 39.7%) on carrageenan compared to the control group. After 2 h, the anti-inflammatory activity decreases sharply (16.2%). This activity completely disappeared after 4 h under TUKEY test.
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