产品
编 号:F757285
分子式:C138H215N41O46
分子量:3184.43
产品类型
结构图
CAS No: 309244-90-4
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产品详情
生物活性:
Amylin (8-37) (human) (hIAPP (8-37)) is a 8-37 fragment of human islet amyloid polypeptide (IAPP). The duplex folding structure in the Amylin (8-37) (human) assembly has a hairpin structure.
体外研究:
Human islet amyloid polypeptide (hIAPP, amylin) is a major component in pancreatic amyloid deposits. Human IAPP with 37 amino acid residues is known to form soluble aggregates that further assemble into protofibrils and mature fibrils and eventually develop into plagues, and many studies have been conducted to identify the core regions with amyloidogenic properties. The assembly structures of Amylin (8-37) (human) (hIAPP (8-37)) shows lamella structures. The C terminal strands of Amylin (8-37) (human) peptides are stabilized by the coassembly molecule 4Bpy.