产品
编 号：F757932
分子式：C105H160N36O21S4
分子量：2390.88
分子式：C105H160N36O21S4
分子量：2390.88
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CAS No: 381725-58-2
产品详情
生物活性：
Conopeptide rho-TIA is a peptide derived from the venom contained in the predatory sea snail Conus tulipa, has highly selective and noncompetitive inhibitor at human α1B-Adrenergic Receptor. Conopeptide rho-TIA acts a competitive inhibitor at human α1A-Adrenergic Receptor and α1D-Adrenergic Receptor. Conopeptide rho-TIA binds to each subtype and may provide useful information for the development of novel α1-Adrenergic Receptor subtype-selective drugs.
体外研究：
Conopeptide rho-TIA (100 nM, 24-48 h) 以非竞争性、可逆的方式与人 α1B-Adrenergic Receptor，这表明conopeptide rho-TIA 可能是一种异位抑制剂。Conopeptide rho-TIA (30 nM, 2 h) 对人 α1B-Adrenergic Receptor 是一种非竞争性抑制剂，而对α1A-Adrenergic Receptor 和 α1D-Adrenergic Receptor 亚型则是一种竞争性抑制剂。Conopeptide rho-TIA (10 μM, one time) 抑制去甲肾上腺素引发的 α1 肾上腺素受体介导的胞浆 Ca2+ 浓度升高，但不影响突触前 α2 肾上腺素受体介导的反应。
Conopeptide rho-TIA is a peptide derived from the venom contained in the predatory sea snail Conus tulipa, has highly selective and noncompetitive inhibitor at human α1B-Adrenergic Receptor. Conopeptide rho-TIA acts a competitive inhibitor at human α1A-Adrenergic Receptor and α1D-Adrenergic Receptor. Conopeptide rho-TIA binds to each subtype and may provide useful information for the development of novel α1-Adrenergic Receptor subtype-selective drugs.
体外研究：
Conopeptide rho-TIA (100 nM, 24-48 h) 以非竞争性、可逆的方式与人 α1B-Adrenergic Receptor，这表明conopeptide rho-TIA 可能是一种异位抑制剂。Conopeptide rho-TIA (30 nM, 2 h) 对人 α1B-Adrenergic Receptor 是一种非竞争性抑制剂，而对α1A-Adrenergic Receptor 和 α1D-Adrenergic Receptor 亚型则是一种竞争性抑制剂。Conopeptide rho-TIA (10 μM, one time) 抑制去甲肾上腺素引发的 α1 肾上腺素受体介导的胞浆 Ca2+ 浓度升高，但不影响突触前 α2 肾上腺素受体介导的反应。
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