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编 号：F758985
分子式：C44H66N8O14S
分子量：963.11
分子式：C44H66N8O14S
分子量：963.11
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CAS No: 57448-84-7
产品详情
生物活性：
Pentagastrin (ICI-50123) meglumine is a potent, selective Cholecystokinin B (CCKB) receptor antagonists with IC50 values of 11 nM and 1100 nM for CCKB and CCKA, respectively. Pentagastrin meglumine enhances gastric mucosal defense mechanisms against acid and protects the gastric mucosa from experimental injury..
体内研究：
Pentagastrin (ICI-50123) meglumine (80 μg/kg/h; i.v.; male Sprague-Dawley rats) protects rat gastric mucosa from acidified aspirin injury.Animal Model:Male Sprague-Dawley rats
Dosage:80 μg/kg/h
Administration:Intravenous injection
Result:Protected rat gastric mucosa from acidified aspirin injury. Induced a hyperaemic response to luminal acid challenge, increased mucus gel thickness, and elevated pHi during acid challenge.
体外研究：
Pentagastrin (ICI-50123) meglumine (0.1-100 μM; GH3-cells) increases intracellular Ca2+ in a dose-dependent manner with a maximal increase of 2.77-fold.Pentagastrin (ICI-50123) meglumine (0.1-100 μM; GH3-cells) bounds dose dependently to GH3 cells.
Pentagastrin (ICI-50123) meglumine is a potent, selective Cholecystokinin B (CCKB) receptor antagonists with IC50 values of 11 nM and 1100 nM for CCKB and CCKA, respectively. Pentagastrin meglumine enhances gastric mucosal defense mechanisms against acid and protects the gastric mucosa from experimental injury..
体内研究：
Pentagastrin (ICI-50123) meglumine (80 μg/kg/h; i.v.; male Sprague-Dawley rats) protects rat gastric mucosa from acidified aspirin injury.Animal Model:Male Sprague-Dawley rats
Dosage:80 μg/kg/h
Administration:Intravenous injection
Result:Protected rat gastric mucosa from acidified aspirin injury. Induced a hyperaemic response to luminal acid challenge, increased mucus gel thickness, and elevated pHi during acid challenge.
体外研究：
Pentagastrin (ICI-50123) meglumine (0.1-100 μM; GH3-cells) increases intracellular Ca2+ in a dose-dependent manner with a maximal increase of 2.77-fold.Pentagastrin (ICI-50123) meglumine (0.1-100 μM; GH3-cells) bounds dose dependently to GH3 cells.
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