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编 号：F759201
分子式：C13H11N3OS
分子量：257.31
分子式：C13H11N3OS
分子量：257.31
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CAS No: 613262-61-6
产品详情
生物活性：
M62812 (free base) is a toll-like receptor 4 (TLR4) signal transduction inhibitor. M62812 can suppress endothelial cell and leukocyte activation and prevents lethal septic shock in mice. M62812 can be used for the research of sepsis.
体内研究：
M62812 (i.v.; 10-20 mg/kg; single) 在小鼠 d-半乳糖胺致敏内毒素休克模型中保护小鼠免受致死并降低炎症和凝血参数。M62812 (20 mg/kg/day) 在小鼠盲肠结扎和穿刺模型中防止小鼠死亡。Animal Model:D-galactosamine-sensitized endotoxin shock mouse model
Dosage:10-20 mg/kg
Administration:Single intravenous administration
Result:Suppressed LPS-induced leukocyte and endothelial cell activation in vivo.Prolonged survival in a d-galactosamine-sensitized endotoxin shock mouse model.
Animal Model:A cecal ligation and puncture mouse model
Dosage:20 mg/kg
Administration:Intravenous administration; Everyday
Result:Reduced mortality in a murine cecal ligation and puncture model.
体外研究：
M62812 (0-10 μg/ml) 抑制人血管内皮细胞和外周单核细胞中 LPS 诱导的炎性细胞因子、粘附分子和促凝活性的上调。
M62812 (free base) is a toll-like receptor 4 (TLR4) signal transduction inhibitor. M62812 can suppress endothelial cell and leukocyte activation and prevents lethal septic shock in mice. M62812 can be used for the research of sepsis.
体内研究：
M62812 (i.v.; 10-20 mg/kg; single) 在小鼠 d-半乳糖胺致敏内毒素休克模型中保护小鼠免受致死并降低炎症和凝血参数。M62812 (20 mg/kg/day) 在小鼠盲肠结扎和穿刺模型中防止小鼠死亡。Animal Model:D-galactosamine-sensitized endotoxin shock mouse model
Dosage:10-20 mg/kg
Administration:Single intravenous administration
Result:Suppressed LPS-induced leukocyte and endothelial cell activation in vivo.Prolonged survival in a d-galactosamine-sensitized endotoxin shock mouse model.
Animal Model:A cecal ligation and puncture mouse model
Dosage:20 mg/kg
Administration:Intravenous administration; Everyday
Result:Reduced mortality in a murine cecal ligation and puncture model.
体外研究：
M62812 (0-10 μg/ml) 抑制人血管内皮细胞和外周单核细胞中 LPS 诱导的炎性细胞因子、粘附分子和促凝活性的上调。
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